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李锐
作者:  发布时间:2014-09-18  浏览次数:

 

姓名:李锐                                                           

职务、职称:副教授、硕导

系别:预防医学系

联系电话:027-68758648

邮箱:rli@whu.edu.cn


个人简介:

    2008年毕业于武汉大学生命科学院生物学基地班,获理学学士学位;2013年毕业于美国田纳西大学营养系,获博士学位;2013年7月加入武汉大学公共卫生学院营养与食品卫生系。

 

主要研究课题:1. 维生素A对肝脏葡萄糖和脂质代谢的影响

               2. 进食频率和进食时间对动物体重的影响

代表性论著 :

1. Li, R., Zhang, R., Li, Y., Zhu, B., Chen, W., Zhang, Y., Chen, G. (2014). An RARE of Hepatic Gck Promoter Interacts with RARα , HNF4α , and COUP-TFII that Affect Retinoic Acid- and Insulin-induced Gck expression. J Nutr Biochem. 25 (9): 964-976.

2. Howell, M., Li, R., Zhang, R., Li, Y., Chen, W., Chen, G. (2013). The expression of Apoc3 mRNA is regulated by HNF4α and COUP-TFII, but not acute retinoid treatments, in primary rat hepatocytes and hepatoma cells. Mol Cell Biochem. 387 (1-2): 241-250.

3. Li, Y., Zhang, Y., Li, R., Chen, W., Howell, M., Zhang, R., and Chen, G. (2012). The Hepatic Raldh1 Expression Is elevated in Zucker Fatty Rats and Its Over-Expression Introduced the Retinal-Induced Srebp-1c Expression in INS-1 Cells. PLoS One 7, e45210.

4. Liu, L., Cao, Z., Chen, J., Li, R., Cao, Y., Zhu, C., Wu, K., Wu, J., Liu, F., and Zhu, Y. (2012). Influenza A Virus Induces Interleukin-27 through Cyclooxygenase-2 and Protein Kinase A Signaling. Journal of Biological Chemistry 287, 11899-11910.

5. Zhao, S., Li, R., Li, Y., Chen, W., Zhang, Y., and Chen, G. (2012). Roles of vitamin A status and retinoids in glucose and fatty acid metabolism. Biochem Cell Biol. 90 (2): 142-152.

6. Zhang, Y., Chen, W., Li, R., Li, Y., Ge, Y., and Chen, G. (2011). Insulin-regulated Srebp-1c and Pck1 mRNA expression in primary hepatocytes from zucker fatty but not lean rats is affected by feeding conditions. PLoS One 6, e21342.

7. Ge, Y., Zhang, Y., Li, R., Chen, W., Li, Y., and Chen, G. (2011). Berberine regulated Gck, G6pc, Pck1 and Srebp-1c expression and activated AMP-activated protein kinase in primary rat hepatocytes. Int J Biol Sci 7, 673-684.

8. Zhang, Y., Li, R., Chen, W., Li, Y., and Chen, G. (2011). Retinoids induced Pck1 expression and attenuated insulin-mediated suppression of its expression via activation of retinoic acid receptor in primary rat hepatocytes. Mol Cell Biochem 355, 1-8.

9. Li, R., Chen, W., Li, Y., Zhang, Y., and Chen, G. (2011). Retinoids synergized with insulin to induce Srebp-1c expression and activated its promoter via the two liver X receptor binding sites that mediate insulin action. Biochem Biophys Res Commun 406, 268-272.

10. Liu, L., Li, R., Pan, Y., Chen, J., Li, Y., Wu, J., and Zhu, Y. (2011). High-throughput screen of protein expression levels induced by cyclooxygenase-2 during influenza a virus infection. Clin Chim Acta 412, 1081-1085.

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