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李得加
作者:  发布时间:2014-09-17  浏览次数:

 

姓名:李得加

职务、职称: 副系主任、教授、博士生导师、楚天学者

系别:预防医学系

联系电话:18271470520

邮箱:80938299@qq.com

 

个人简介:

2005年博士毕业于武汉大学生命科学学院,2006年受Dongsheng Duan教授邀请赴美国从事博士后研究,在美国University of Missouri-columbia 工作期间,发表研究论文11篇。2011年回国后,在The Journal of Biological Chemistry, Molecuar Therapy-Nucleic Acids,Oncotarget, Aging-US,Journal of Gastroenterology, Journal of Applied Physiology, Molecular Biosystems等与本专业相关的专业杂志上发表通讯作者论文23篇。其中4篇入选ESI 2017高被引论文,到目前为止共发表论文63篇,其中SCI收录论文42篇。现为农工党武大医学部支部主委,美国基因治疗协会会员,湖北省预防医学会理事,武汉市预防医学会环境卫生学委员会常务副主任委员。SCI期刊Current Pharmaceutical Design特刊客座编辑,中科院二区SCI期刊journal of translational medicine副主编。国际期刊American Journal of Pathology, The Journal of Endocrinology & Metabolism, Cacner Letters, Molecular Cancer, International Journal of Cancer, Scientific Report, Oncotarget, Molecular Therapy-Nucleus Acids, Carcinogenesis和Aging-US等SCI期刊审稿人。

 

主要研究领域:肺癌发病机制、非编码RNA在肿瘤中的生物学功能、RNA可变剪切。

 

主要研究课题:

新肺癌分子标记物 miRNA 在肺癌发生、诊断和治疗中的作用(武汉市高新技术产业科技创新团队培养计划) 项目负责人

Sirt1对萎缩肌肉再生能力影响机制的研究(湖北省自然科学基金) 项目负责人

Sirt1在杜氏肌营养不良症中作用机制的研究 (国家自然科学基金) 项目负责人

综合干预对Klotho基因表观遗传影响及其与心血管危险因素关联性研究(国家自然科学基金) 第一参与人

 

3年代表性通讯作者论著

1.      Pan, JY*, Zhang, F*, Sun, CC*#, Li, SJ, Li, G, Gong, FY, He, J, Hua, RX, Hu, WD, Yuan, ZP, Wang, X, He, QQ and Li, DJ#. MiR-134: a human cancer suppressor? Mol Ther Nucleic Acids, 2017. 6(1): doi: 10.1016/j.omtn.2016.11.003. (IF 5.048)

2.      Sun, C, Li, S, Yuan, Z, Li, D. MicroRNA-346 facilitates cell growth and metastasis, and suppresses cell apoptosis in human non-small cell lung cancer by regulation of XPC/ERK/Snail/E-cadherin pathway. Aging.2016, 8(10), 1509-24. (IF 3.979)

3.      Sun, CC, Li, SJ, Zhang, F, Zhang, Y, Zuo, Z, Xi, YY, Wang, L, and Li, DJ. The novel miR-9600 suppresses tumor progression and promotes paclitaxel sensitivity in non-small cell lung cancer (NSCLC) through altering STAT3 expression. Mol Ther Nucleic Acids, 2016. 5(11): e387. (IF 5.048)

4.      Sun, CC, Li, SJ, Li G, Hua, R, Zhou, XH, Li, DJ. Long intergenic non-coding RNA 00511 acts as an oncogene in non-small cell lung cancer by binding to EZH2 and suppressing p57. Mol Ther Nucleic Acids, 2016. 5(11): e385. (IF 5.048)

5.      Sun, C, Li, S, Zhang, F, Xi, Y, Wang, L, Fu, Z, Zhang, Y, Bi, Y, and Li, D. Long non-coding RNA NEAT1 promotes non-small cell lung cancer progression through regulation of miR-377-3p-E2F3 pathway. Oncotarget.2016, 7(32), 51784-51814. (IF 5.008)

6.      Sun, C, Li, S, Li, D. Hsa-miR-134 suppresses non-small cell lung cancer (NSCLC) development through down-regulation of CCND1. Oncotarget.2016, 7(24), 35960-35978. (IF 5.008)

7.      Yang C*, Sun C*, Liang X, Xie S, Huang J, and Li D. Integrative analysis of microRNA and mRNA expression profiles in non-small-cell lung cancer. Cancer Gene Therapy.2016, 23(4):90-97. (IF 2.532

8.      Sun, C, Li, S, Yang, C, Xi, Y, Wang, L, Zhang, F and Li D. MicroRNA-187-3p mitigates non-small cell lung cancer (NSCLC) development through down-regulation of BCL6. Biochem Biophys Res Commun:2016;471:82-88. (IF 2.371)

9.      Sun, CC, Li, SJ, Zhang, F, Pan, JY, Wang, L, Yang, CL Xi, YY, Wang, L and Li DJ. Hsa-miR-329 exerts tumor suppressor function through down-regulation of MET in non-small cell lung cancer. Oncotarget, 7(16):21510-21526. (IF 5.008)

10.  Sun, C, Huang, C, Li, S, Yang, C, Xi, Y, Wang, L and Li D. Hsa-miR-326 targets CCND1 and inhibits non-small cell lung cancer development. Oncotarget.2016, 7(7):8341-8359. (IF 5.008)

11.  Sun C, Li S and Li D. Sulforaphane mitigates muscle fibrosis in mdx mice via Nrf2-mediated inhibition of TGF-beta/Smad signaling. J Appl Physiol (1985). 2016; 120:377-390. (IF 3.004)

12.  Sun, Cheng-Cao, Li, Shu-Jun, Yang, Cui-Li, Xue, Rui-Lin, Xi, Yong-Yong, Wang, Liang, Zhao, Qian-Long, Li, De-Jia, Sulforaphane Attenuates Muscle Inflammation in Dystrophin-deficient mdx Mice via NF-E2-related Factor 2 (Nrf2)-mediated Inhibition of NF-kappaB Signaling Pathway., Journal of Biological Chemistry, 2015.7.17, 290(29):17784~17795

13.  Sun, Chengcao, Yang, Cuili,Xue, Ruilin, Li, Shujun, Zhang, Ting, Pan, Lei, Ma, Xuejiao, Wang, Liang, Li, Dejia, Sulforaphane alleviates muscular dystrophy in mdx mice by activation of Nrf2., J Appl Physiol (1985), 2015.1.15, 118(2):224~237

14.  Chengcao Sun, Ming Sang, Shujun Li, Xiaodong Sun, Cuili Yang, Yongyong Xi, Liang Wang, Feng Zhang, Yongyi Bi, Yunfeng Fu, Dejia Li, Hsa-miR-139-5p inhibits proliferation and causes apoptosis associated with down-regulation of c-Met, Oncotarget, 2015.11.25, 6(37):39756~39792

15.  Huang, Chuan-Feng, Sun, Cheng-Chao, Zhao, Fang, Zhang, Ya-Dong, Li, De-Jia, miR-33a levels in hepatic and serum after chronic HBV-induced fibrosis., Journal of Gastroenterology, 2015.4.01, 50(4):480~490

16.  Chengcao Sun, Zhidong Liu, Shujun Li, Cuili Yang, Ruilin Xue, Yongyong Xi, Liang Wang, Suqing Wang, Qiqiang He, Jie Huang, Songping Xie, Wenyang Jiang, Dejia Li, Down-regulation of c-Met and Bcl2 by microRNA-206, activates apoptosis, and inhibits tumor cell proliferation, migration and colony formation, Oncotarget, 2015.9.22, 6(28):25533~25574

17.  Huang, Junchao, Sun, Chengchao, Wang, Suqing, He, Qiqiang,  Li, Dejia, microRNA miR-10b inhibition reduces cell proliferation and promotes apoptosis in non-small cell lung cancer (NSCLC) cells., Mol Biosyst, 2015.7.01, 11(7):2051~2059

18.  Wang, Liang, Xi, Yongyong, Sun, Chengcao, Zhang, Feng, Jiang, Heng, He, Qiqiang, Li, Dejia, CDK3 is a major target of miR-150 in cell proliferation and anti-cancer effect, Exp Mol Pathol, 2017.1.17, 102(2):181~190

19.  Xue, Ruilin, Yang, Cuili, Zhao, Fang, Li, Dejia, Prognostic significance of CDH13 hypermethylation and mRNA in NSCLC., OncoTargets and Therapy, 2014.01.01, 7:1987~1996

20.   Xi, Yongyong, Wang, Liang, Sun, Chengcao, Yang, Cuili, Zhang, Feng, Li, Dejia,The novel miR-9501 inhibits cell proliferation, migration and activates apoptosis in non-small cell lung cancer, Medical Oncology, 2016.11.01, 33(11)

21.  Wang Liang, Xue Ruilin, Sun Chengcao, Yang Cuili, Xi Yongyong, Zhang Feng, He Qiqiang, Wang Suqing, Zhao Fang, Zhang Yadong, Li Dejia, SIRT1 regulates C2C12 myoblast cell proliferation by activating Wnt signaling pathway, Int J Clin Exp Pathol, 2016.3.15, 9(3):2857~2868

22.   Cuili Yang, Lei Pan, Chengcao Sun, Yongyong Xi, Liang Wang, Dejia Li, Red Meat Consumption and the Risk of Stroke: A Dose–Response Meta-analysis of Prospective Cohort Studies, Journal of Stroke and Cerebrovascular Diseases, 2016.5.01, 25(5):1177~1186

23.  Liang Wang, Ting Zhang, Yongyong Xi, Cuili Yang, Chengcao Sun, Dejia Li, Sirtuin 1 promotes the proliferation of C2C12 myoblast cells via the myostatin signaling pathway, Molecular Medicine Reports, 2016.5.27, 14:1309~1315

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